PAEA Surgery End Of Rotation (EOR) Practice Exam

What syndrome may be increased by the concomitant use of opiates and vancomycin?

1. Stevens-Johnson syndrome

2. Red man syndrome

3. Anaphylaxis

4. Serotonin syndrome

The correct answer is: Red man syndrome

Red man syndrome is associated with the rapid infusion of vancomycin. It is characterized by flushing, rash, and sometimes hypotension, which can occur due to the direct release of histamine from mast cells triggered by vancomycin. The concomitant use of opiates can exacerbate the hypotensive effects of red man syndrome due to their potential to cause vasodilation and decrease vascular resistance. This interaction can heighten the risk of experiencing more severe symptoms when vancomycin is administered too quickly, amplifying the severity of red man syndrome. The correct answer highlights an important consideration for healthcare providers when administering these medications, particularly in a clinical setting where monitoring for side effects is crucial. Understanding the implications of combining these drugs aids in patient safety and effective management of potential side effects.